Publications

Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K (2015). dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med. 212(7):991-9

Zarkada G, Heinolainen K, Makinen T, Kubota Y, Alitalo K (2015). VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci U S A. 112(3):761-6.

Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, Pollard JW, Gerhardt H, Alitalo K (2011). VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nature Cell Biol 13: 1202-1213.

S. Holmqvist§, Š. Lehtonen§, M. Chumarina, K.A. Puttonen, C. Azevedo, L. Olga, M. Ruponen,, M. Oksanen, A. Collin, S. Goldwurm, M. Meyer, M. Lagarkova, S. Kiselev, J. Koistinaho, L. Roybon (2016). Creation of a library of induced pluripotent stem cell models from Parkinsonian patients. NPJ Parkinson’s Disease. 2, 16009.

M. Djelloul, S. Holmqvist, A.B. Serrano, C. Azevedo, M. Yeung, M. S. Goldwurm, J. Frisén, T. Deierborg, L. Roybon (2015). Alpha-synuclein expression identified during oligodendrocyte differentiation using rodent primary cultures and new human pluripotent stem cell models of synucleinopathies. Stem Cell Reports. Aug 11;5(2):174-84. Lazarevic I and B Engelhardt (2016). Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suitable to study immune cell migration across this brain barrier. Fluids Barriers CNS. 2016 Jan 29;13(1):2.

Engelhardt B, P Vajkoczy, RO Weller (2017). Movers and shapers of immuneprivilege of the CNS. Nature Immunol 18(2):123-131.

Engelhardt B, Carare RO, Bechmann I, Flügel A, Laman JD, Weller RO (2016). Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta Neuropathol. 132:317-38. Epub Aug 13

Szalay G, Martinecz B, Lénárt N, Környei Z, Orsolits B, Judák L, Császár E, Fekete R, West BL, Katona G, Rózsa B, Dénes Á (2016). Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke. Nat Commun 3:7:11499

Orlova, V. V., Drabsch, Y., Freund, C., Petrus-Reurer, S., van den Hil, F. E., Muenthaisong, S., Dijke, P. T., and Mummery, C. L. (2014). Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts. Arterioscler. Thromb. Vasc. Biol.. 34, 177–186

Orlova, V. V., van den Hil, F. E., Petrus-Reurer, S., Drabsch, Y., Dijke, ten, P., and Mummery, C. L.(2014). Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells. Nature Protocols. 9,1514–1

Van Der Meer, A. D., Orlova, V. V., Dijke, ten, P., van den Berg, A., and Mummery, C. L. (2013). 3-D co-cultures of human endothelial cells and hESC-derived pericytes inside a microfluidic device. Lab Chip 13, 3562-8

Montañola A, de Retana SF, López-Rueda A, Merino-Zamorano C, Penalba A, Fernández-Álvarez P, Rodríguez-Luna D, Malagelada A, Pujadas F, Montaner J, Hernández-Guillamon M (2016). ApoA1, ApoJ and ApoE Plasma Levels and Genotype Frequencies in Cerebral Amyloid Angiopathy. Neuromolecular Med.18(1):99-108.

Morancho A, Hernández-Guillamon M, Boada C, Barceló V, Giralt D, Ortega L, Montaner J, Rosell A (2013). Cerebral Ischemia and Matrix Metalloproteinase-9 Modulate the Angiogenic Function of Endothelial Progenitor. Cells. J Cell Mol Med. 14(12):1543-53.

Korhonen P, Kanninen KM, Lehtonen Š, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, Kidin I, García-Berrocoso T, Giralt D, Montaner J, Koistinaho J, Malm T (2015). Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. Brain Behav Immun. doi: 10.1016/j.bbi.2015.06.013.

Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J. (2009). Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 106(38):16505- 10.

Steffen BJ, Breier G, Butcher EC, Schulz M, Engelhardt B  (1996). ICAM-1, VCAM-1, and MAdCAM-1 are expressed on choroid plexus  epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol .148(6):1819-38.

Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B,  Sallusto F (2009). C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus  is required for the initiation of EAE. Nat Immunol . 10(5):514-23.

Carare RO, Bernardes-Silva M, Newman TA, Page AM, Nicoll JAR, Perry VH, Weller RO (2008). Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries. Significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathology and Applied Neurobiology 34(2):131-44.

Hawkes CA, Härtig W, Kacza J, Schliebs R, Weller R.O, Nicoll JAR,  Carare RO (2011) Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy.  Acta Neuropathologica, 121(4), 431-443

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O’Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M.  (2013) Sleep Drives Metabolite Clearance from the Adult Brain. Science  342(6156):373-7. PMC3880190.

Sun W, McConnell E, Pare JF, Xu Q, Chen M, Lovatt D, Han X, Smith Y, Nedergaard M . (2013) Glutamate-dependent neuroglial calcium signaling differs between young and adult brain. Science  339:197-200. PMC356900

Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M , Attwell D (2014): Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508:55-60.

Lind BL, Brazhe AR, Jessen SB, Tan FC, Lauritzen MJ  (2013): Rapid stimulus-evoked astrocyte Ca2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo. Proc Natl Acad Sci U S A  110:E4678-E4687

Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S, Terwel D, Walter J, Pape HC, König, S, Roeber S, Jessen F, Klockgether T, Korte M, Heneka MT (2011) Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation. Neuron 71: 833-844.

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 493: 674-678.

Szigeti K, Horváth I, Veres DS, Martinecz B, Lénárt N, Kovács N, Bakcsa E, Márta A, Semjéni M, Máthé D, Dénes Á* (2015). A novel SPECT-based approach reveals early mechanisms of central and peripheral inflammation after cerebral ischemia. J Cereb Blood Flow Metab Dec;35(12):1921-9